Efficacy of afoxolaner against Dermacentor variabilis ticks in dogs
| Autor: | Paul M. Dorr, Theodore S. Chester, Elizabeth B. Mitchell, William R. Everett, Diane Larsen |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Veterinary medicine Oral treatment medicine.disease_cause Beagle Random Allocation Ticks Dogs Afoxolaner Infestation parasitic diseases medicine Animals Dog Diseases Dermacentor variabilis Acaricides Dermacentor General Veterinary biology integumentary system Acaricide General Medicine biology.organism_classification veterinary(all) Tick Infestations Treatment Outcome Parasitology Female After treatment |
| Zdroj: | Veterinary parasitology. 201(3-4) |
| ISSN: | 1873-2550 |
| Popis: | Efficacy of afoxolaner, a novel isoxazoline insecticide/acaricide, against Dermacentor variabilis ticks was confirmed in two laboratory studies. Each study utilized a controlled, randomized block design. One day prior to treatment, beagle dogs were infested with 50 unfed adult ticks. Repeat infestations were performed weekly for four weeks. The number of live ticks remaining on each dog was determined 48h after treatment and after each subsequent infestation. A single oral treatment with a dose approaching the minimum effective dose of afoxolaner (2.5mg/kg) eliminated the pre-existing infestations by D. variabilis ticks and controlled weekly re-infestations with 99.7–100% efficacy up to Day 23 and >97% efficacy at Day 30. |
| Databáze: | OpenAIRE |
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