Fetal pericallosal lipomas – Clues to diagnosis in the second trimester
| Autor: | Monica Echevarria Telleria, Z. Leibovitz, Carmina Bermejo, Hector Quiroga, F. Viñals, Gustavo Malinger, Raquel García, Liat Ben-Sira, Joseph Har-Toov, Shiri Shinar, Tally Lerman-Sagie |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Neurological examination Corpus callosum Ultrasonography Prenatal Corpus Callosum 030218 nuclear medicine & medical imaging 03 medical and health sciences Fetus 0302 clinical medicine Pregnancy Second trimester Prenatal Diagnosis Humans Medicine medicine.diagnostic_test business.industry Ultrasound General Medicine Lipoma medicine.disease Magnetic Resonance Imaging Early Diagnosis Pregnancy Trimester Second Agenesis Pediatrics Perinatology and Child Health Female Neurology (clinical) Radiology Differential diagnosis business 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Paediatric Neurology. 22:929-934 |
| ISSN: | 1090-3798 |
| DOI: | 10.1016/j.ejpn.2018.07.011 |
| Popis: | Introduction Pericallosal lipomas (PCL) are congenital soft masses of adipose cells encapsulated by a thin layer of fibrous tissue, appearing adjacent to the corpus callosum (CC). The lipomas are usually diagnosed prenatally during the third trimester. The purpose of this study was to identify 2nd trimester ultrasound findings that may hint to a later diagnosis of PCL and to evaluate their MRI evolution. Methods A multicenter study of fetuses diagnosed during the 3rd trimester with a PCL in 7 fetal ultrasound units between 2001 and 2017. We reevaluated the ultrasound and MRI images starting from the referral examination and until the time of diagnosis, searching for clues that could have prompted an earlier diagnosis. Parents were contacted at the end of the study period to obtain information regarding development and neurological examination. Results Fifteen patients with PCL were diagnosed during the study period; fourteen had second trimester scans. A 2nd trimester diagnosis was established in only 2 (13.3%). Anomalies of the CC were evident in 8/14 patients during the 2nd trimester scan and included: short length (n = 4), increased thickness (n = 1), complete agenesis (n = 2) and partial agenesis (n = 1). Third trimester ultrasound scans were considered diagnostic of PCL in all 12 remaining cases, in eight it was considered an isolated finding. Postnatal neurological evaluation in the isolated cases revealed normal development in all children. One child was diagnosed with attention deficit disorder. Conclusions Non visualization of a PCL during the 2nd trimester is common, and should not be considered a diagnostic error. An underlying PCL should be included in the differential diagnosis of CC anomalies during this time period, necessitating further follow up into the 3rd trimester. |
| Databáze: | OpenAIRE |
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