Identifying firing mammalian neurons in networks with high-resolution multi-transistor array (MTA)

Autor:	Roland Thewes, V. Vitzthum, Max Eickenscheidt, Peter Fromherz, B. Eversmann, Armin Lambacher, R. Zeitler
Rok vydání:	2010
Předmět:	Physics Chemistry(all) Basis (linear algebra) business.industry Transistor Analytical chemistry Transistor array High resolution General Chemistry law.invention Amplitude Materials Science(all) CMOS law Optoelectronics General Materials Science business Image resolution Voltage
Zdroj:	Applied Physics A. 102:1-11
ISSN:	1432-0630 0947-8396
DOI:	10.1007/s00339-010-6046-9
Popis:	The electrical activity of a network of mammalian neurons is mapped with a Multi-Transistor Array (MTA) fabricated with extended CMOS technology. The spatial resolution is 7.4 μm on an area of 1 mm2 at a sampling frequency of 6 kHz for a complete readout of 16,384 sensor transistors. Action potentials give rise to extracellular voltages with amplitudes in a range of 500 μV. On the basis of the high resolution in space and time, correlation algorithms are used to identify single action potentials with amplitudes as low as about 200μV, and to assign the signals to the activity of individual neurons even in a dense network.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f2ea2b2cadd389a8855f1dc43ffc08 https://doi.org/10.1007/s00339-010-6046-9 Zobrazit plný text záznamu Full text from SpringerLink