Suppressive effect of anti-rheumatic drugs on interleukin-1 beta release from human peripheral blood monocytes
| Autor: | Makoto Goto, Keiko Nakamura, Kusuki Nishioka, Masahiro Okamoto, Minoru Sasano, Ryuichi Yokohari, Shinichi Aotsuka |
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| Rok vydání: | 1991 |
| Předmět: |
Drug
Auranofin media_common.quotation_subject Immunology Enzyme-Linked Immunosorbent Assay Ibuprofen Pharmacology In Vitro Techniques Lobenzarit Monocytes medicine Humans Cysteine media_common business.industry Penicillamine Bucillamine Anti-Inflammatory Agents Non-Steroidal Interleukin medicine.disease Rheumatoid arthritis business Immunosuppressive Agents medicine.drug Interleukin-1 |
| Zdroj: | International journal of immunopharmacology. 13(1) |
| ISSN: | 0192-0561 |
| Popis: | We developed an ELISA system for human IL-1 alpha and -beta release from silica-stimulated monocytes from healthy volunteers and tested the effect of several anti-rheumatic drugs including nonsteroidal anti-inflammatory drug (Ibuprofen). Anti-rheumatic drugs including Auranofin and Sulphasalazine suppressed IL-1 beta release significantly at therapeutic concentrations, whereas Bucillamine, Lobenzarit, D-Penicillamine and Ibuprofen did not. These results suggest a possible immunotherapeutic effectiveness of some anti-rheumatic drugs on rheumatoid arthritis through their inhibition of IL-1 beta release. |
| Databáze: | OpenAIRE |
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