Targeted Antibiotic Delivery: Selective Siderophore Conjugation with Daptomycin Confers Potent Activity against Multidrug Resistant Acinetobacter baumannii Both in Vitro and in Vivo
| Autor: | Mark A. Suckow, Ute Möllmann, Manuka Ghosh, William D. Claypool, Li Shuang, Weiqiang Huang, Valerie A. Schroeder, Jaroslav Zajicek, William R. Wolter, Honglin Yu, Marvin J. Miller, Patricia A. Miller |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Acinetobacter baumannii Siderophore medicine.drug_class Antibiotics Siderophores Drug resistance Pharmacology In Vitro Techniques 01 natural sciences Microbiology 03 medical and health sciences Daptomycin In vivo Drug Resistance Multiple Bacterial Drug Discovery medicine Humans biology 010405 organic chemistry Chemistry biology.organism_classification 0104 chemical sciences Multiple drug resistance 030104 developmental biology Molecular Medicine Bacteria medicine.drug |
| Zdroj: | Journal of medicinal chemistry. 60(11) |
| ISSN: | 1520-4804 |
| Popis: | In order to address the dire need for new antibiotics to treat specific strains of drug resistant Gram-negative bacterial infections, a mixed ligand analog of the natural Acinetobacter baumannii selective siderophore, fimsbactin, was coupled to daptomycin, a Gram-positive only antibiotic. The resulting conjugate 11 has potent activity against multidrug resistant strains of A. baumannii both in vitro and in vivo. The study also indicates that conjugation of siderophores to “drugs” that are much larger than the siderophore (iron transport agent) itself facilitates active uptake that circumvents the normal permeability problems in Gram-negative bacteria. The results demonstrate the ability to extend activity of a normally Gram-positive only antibiotic to create a potent and targeted Gram-negative antibiotic using a bacterial iron transport based sideromycin Trojan horse strategy. |
| Databáze: | OpenAIRE |
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