Gut microbiota development of preterm infants hospitalised in intensive care units
| Autor: | Naoki Tsukuda, Y Watanabe, Kana Yahagi, Hisamichi Tauchi, Hiroyoshi Iwata, Fumihiro Ochi, Toshifumi Yamauchi, Takahiro Matsuki, S Tajima, R Yamaoka, Eiichi Ishii, Masaaki Ohta, S Matsumoto, T Hara |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Male Neonatal intensive care unit 030106 microbiology Physiology Infant health Gut flora Acetates digestive system Microbiology Staphylococcaceae 03 medical and health sciences Feces Enterobacteriaceae Intensive care RNA Ribosomal 16S Medicine Humans Ecosystem development biology business.industry Infant Newborn Hydrogen-Ion Concentration biology.organism_classification Gut microbiome Gastrointestinal Microbiome Bifidobacteriaceae Gram-Positive Cocci Hospitalization Intensive Care Units 030104 developmental biology Metabolome Female Bifidobacterium business Infant Premature |
| Zdroj: | Beneficial microbes. 10(6) |
| ISSN: | 1876-2891 |
| Popis: | Gut microbiome development affects infant health and postnatal physiology. The gut microbe assemblages of preterm infants have been reported to be different from that of healthy term infants. However, the patterns of ecosystem development and inter-individual differences remain poorly understood. We investigated hospitalised preterm infant gut microbiota development using 16S rRNA gene amplicons and the metabolic profiles of 268 stool samples obtained from 17 intensive care and 42 term infants to elucidate the dynamics and equilibria of the developing microbiota. Infant gut microbiota were predominated by Gram-positive cocci, Enterobacteriaceae or Bifidobacteriaceae, which showed sequential transitions to Bifidobacteriaceae-dominated microbiota. In neonatal intensive care unit preterm infants (NICU preterm infants), Staphylococcaceae abundance was higher immediately after birth than in healthy term infants, and Bifidobacteriaceae colonisation tended to be delayed. No specific NICU-cared infant enterotype-like cluster was observed, suggesting that the constrained environment only affected the pace of transition, but not infant gut microbiota equilibrium. Moreover, infants with Bifidobacteriaceae-dominated microbiota showed higher acetate concentrations and lower pH, which have been associated with host health. Our data provides an in-depth understanding of gut microbiota development in NICU preterm infants and complements earlier studies. Understanding the patterns and inter-individual differences of the preterm infant gut ecosystem is the first step towards controlling the risk of diseases in premature infants by targeting intestinal microbiota. |
| Databáze: | OpenAIRE |
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