Comorbidity is an independent prognostic factor in women with uterine corpus cancer: a nationwide cohort study
| Autor: | Marie Louise Nielsen, Mette Calundann Noer, Cecilie Dyg Sperling, Claus Høgdall, Ib Jarle Christensen, Øjvind Lidegaard |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Neoplasm Residual Multivariate analysis Denmark Comorbidity Kaplan-Meier Estimate Adenocarcinoma Cohort Studies Predictive Value of Tests Risk Factors Internal medicine medicine Humans Survival analysis Aged Neoplasm Staging Aged 80 and over Performance status business.industry Carcinoma Hazard ratio Univariate Obstetrics and Gynecology Sarcoma General Medicine Middle Aged Prognosis medicine.disease Surgery Uterine Neoplasms Population study Female Neoplasm Grading business Cohort study |
| Zdroj: | Acta Obstetricia et Gynecologica Scandinavica. 93:325-334 |
| ISSN: | 0001-6349 |
| DOI: | 10.1111/aogs.12338 |
| Popis: | Objective To determine whether comorbidity independently affects overall survival in women with uterine corpus cancer. Design Cohort study. Setting Denmark. Study population A total of 4244 patients registered in the Danish Gynecologic Cancer database with uterine corpus cancer from 1 January 2005 until 13 October 2011. Methods All patients included in the study were assigned a comorbidity score according to the Charlson Comorbidity Index. Multivariate survival analyses were performed to investigate the prognostic impact of comorbidity adjusting for known prognostic factors. As performance status might capture the prognostic impact of comorbidity and because information on the variable grade was missing in some special histological subtypes, we included different models in the multivariate analyses with and without PS and grade, respectively. Main outcome measures Overall survival. Results Univariate survival analysis showed a significant (p |
| Databáze: | OpenAIRE |
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