Cochlear microphonic changes after noise exposure and gentamicin administration during sleep and waking
| Autor: | Marisa Pedemonte, Ricardo A. Velluti, Daniel Drexler |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
business.industry Efferent Guinea Pigs Audiology Efferent Pathways Sleep in non-human animals Sensory Systems Anti-Bacterial Agents Anesthesia Cochlear Microphonic Potentials Animals Medicine Wakefulness Circadian rhythm Gentamicins Noise Sleep business Cochlear microphonic potential Cochlea Noise (radio) Slow-wave sleep |
| Zdroj: | Hearing Research. 194:25-30 |
| ISSN: | 0378-5955 |
| DOI: | 10.1016/j.heares.2004.03.008 |
| Popis: | These experiments were designed to investigate the effect of noise, sleep, and gentamicin on the cochlear microphonic (CM) of the guinea pigs. Are the changes observed due to intrinsic cochlear phenomena or to efferent system actions? To answer this question, noise exposure together with efferent system blockade by gentamicin administration was performed. In the normal (non-treated) animal, noise exposure decreased both variability and amplitude of the tone evoked CM in about the first 10 min while the physiological modulation of slow wave sleep increasing the CM is not present. Following administration of gentamicin, noise no longer affect the CM in about the first 10 min, although it produces amplitude and variability increments. The influence of slow wave sleep on the CM is not altered. Thus, gentamicin does not block the CM sleep/wakefulness related shifts. The data were discussed in terms of the influence of gentamicin on the olivo-cochlear bundle. It was hypothesized that the effects of noise on the CM is a result of both peripheral and central influences. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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