Risk stratification of diffuse large B-cell lymphoma with interim PET-CT based on different cutoff Deauville scores
| Autor: | Jihyun Kim, Sang Eun Kim, Jong Seok Lee, Yoo Sung Song, Won Woo Lee |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Cancer Research Vincristine Cyclophosphamide Kaplan-Meier Estimate Sensitivity and Specificity 03 medical and health sciences Antibodies Monoclonal Murine-Derived 0302 clinical medicine Prednisone Fluorodeoxyglucose F18 Reference Values Interim Positron Emission Tomography Computed Tomography Antineoplastic Combined Chemotherapy Protocols Image Interpretation Computer-Assisted medicine Image Processing Computer-Assisted Cutoff Humans Progression-free survival Aged Neoplasm Staging business.industry Hematology Middle Aged medicine.disease Prognosis Treatment Outcome Oncology Doxorubicin 030220 oncology & carcinogenesis Rituximab Female Lymphoma Large B-Cell Diffuse Nuclear medicine business Diffuse large B-cell lymphoma Biomarkers 030215 immunology medicine.drug |
| Zdroj: | Leukemialymphoma. 59(2) |
| ISSN: | 1029-2403 |
| Popis: | We evaluated the usefulness of interim 18F-FDG PET/CT for risk stratification using different cutoff values of the Deauville 5-point scale (5-DS) in DLBCL patients treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). One hundred and fifty patients underwent interim (I-) and end of treatment (EOT-) PET/CT scans. Applying the conventional 5-DS cutoff value of scores 4 to 5 at interim, there was no significant difference in progression free survival (PFS) between I-PET negative and I-PET positive patients. In comparison, PFS was inferior in patients with a score of 5 on I-PET scan compared with those with a score in between 1 to 4 (28.6% vs. 78.7%, p |
| Databáze: | OpenAIRE |
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