Clinical characteristics and prognostic factors of adult patients with pilocytic astrocytoma

Autor: Georg Widhalm, Matthias Preusser, Felix Sahm, Karl Rössler, Adelheid Wöhrer, Anika Simonovska, Barbara Kiesel, Karl Ungersböck, Stefan Oberndorfer, Anna S. Berghoff, Christine Marosi, Julia Furtner, Johannes A. Hainfellner, Maximilian J. Mair
Rok vydání: 2020
Předmět:
Zdroj: Journal of Neuro-Oncology
ISSN: 1573-7373
0167-594X
DOI: 10.1007/s11060-020-03513-9
Popis: Introduction Pilocytic astrocytoma (PA) is the most common primary brain neoplasm in children and treated in curative intent with gross total resection (GTR). However, PA is rare in adults, resulting in limited knowledge on the natural clinical course. This study aimed to describe the clinical course and identify prognostic factors of adult patients with PA. Methods 46 patients ≥ 18 years at diagnosis of PA and neurosurgical resection or biopsy between 2000 and 2018 were identified from the Neuro-Biobank of the Medical University of Vienna. In two cases with differing histopathological diagnosis at recurrence, DNA methylation analysis was performed using Illumina Infinium HumanMethylation850 BeadChip (850 k) arrays and the Molecular Neuropathology classifier. Clinico-pathological features were correlated with patient outcomes. Results Median age at diagnosis was 32.5 years (range: 19–75) and median Ki67 proliferation index was 2.8% (0.5–13.4%). Tumor location significantly correlated with resectability (p 40 and higher body mass index (BMI) were associated with impaired progression-free and overall survival (p Conclusions Tumor recurrence or progression in adult PA patients was higher than the one reported in pediatric patients. Higher age and BMI were associated with impaired prognosis.
Databáze: OpenAIRE
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