The antitumoral effects of chemerin are independent from leukocyte recruitment and mediated by inhibition of neoangiogenesis
| Autor: | Diana Al Delbany, Anne Lefort, Virginie Robert, Marc Parmentier, Francina Langa, Maxime Vernimmen, Valérie Wittamer, Ingrid Dubois-Vedrenne, Olivier De Henau, Frédérick Libert |
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| Přispěvatelé: | Institut de Recherche Interdisciplinaire en Biologie Humaine et moléculaire = Insitute of Interdisciplinary Research [Bruxelles, Belgique] (IRIBHM), Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Walloon Excellence in Life sciences and BIOtechnology [Liège] (WELBIO), Centre d'Ingénierie génétique murine - Mouse Genetics Engineering Center (CIGM), Institut Pasteur [Paris] (IP), This work was supported by the Belgian programme on Interuniversity Poles of Attraction initiated by the Belgian State, Prime Minister’s Office, Science Policy Programming, the Fonds de la Recherche Scientifique Médicale of Belgium, Télévie, the Fondation Belge contre le Cancer and the Actions de Recherche Concertée to M.P. I.D.V and D.A.D. were supported by FNRS-Télévie grants and I.D.V by the Fondations Rose & Jean Hoguet and David & Alice Van Buuren, O.D.H. was Aspirant of the Belgian Fonds National de la Recherche Scientifique. |
| Rok vydání: | 2021 |
| Předmět: |
biology
Chemistry [SDV]Life Sciences [q-bio] Lewis lung carcinoma Cancer tumor angiogenesis Sciences bio-médicales et agricoles CMKLR1 medicine.disease Umbilical vein Sciences humaines ChemR23 Oncology In vivo biology.protein Cancer research medicine Chemerin Receptor B16 melanoma chemerin Rarres2 Research Paper |
| Zdroj: | Oncotarget Oncotarget, 12 (19 Oncotarget, 2021, 12 (19), pp.1903-1919. ⟨10.18632/oncotarget.28056⟩ |
| ISSN: | 1949-2553 |
| Popis: | International audience; Chemerin, a multifunctional protein acting through the receptor ChemR23/CMKLR1, is downregulated in various human tumors and was shown to display antitumoral properties in mouse models of cancer. In the present study, we report that bioactive chemerin expression by tumor cells delays the growth of B16 melanoma and Lewis lung carcinoma in vivo. A similar delay is observed when chemerin is not expressed by tumor cells but by keratinocytes of the host mice. The protective effect of chemerin is mediated by CMKLR1 and appears unrelated to the recruitment of leukocyte populations. Rather, tumors grown in the presence of chemerin display a much smaller number of blood vessels, hypoxic regions early in their development, and larger necrotic areas. These observations likely explain the slower growth of the tumors. The anti-angiogenic effects of chemerin were confirmed in a bead sprouting assay using human umbilical vein endothelial cells. These results suggest that CMKLR1 agonists might constitute therapeutic molecules inhibiting the neoangiogenesis process in solid tumors. |
| Databáze: | OpenAIRE |
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