How Do Animals Survive Extreme Temperature Amplitudes? The Role of Natural Deep Eutectic Solvents
| Autor: | Ana Catarina Freire Gertrudes, Ana Rita C. Duarte, Zahara Saoud Faria Eltayari, Rita Craveiro, Rui L. Reis, Alexandre Paiva |
|---|---|
| Přispěvatelé: | Universidade do Minho |
| Rok vydání: | 2017 |
| Předmět: |
Glycerol
0301 basic medicine Cryobiology General Chemical Engineering 02 engineering and technology Extreme temperature Cryopreservation 03 medical and health sciences Cryoprotective Agent Cryoprotective agents Environmental Chemistry Vitrification Choline derivatives Eutectic system Science & Technology Ice crystals Renewable Energy Sustainability and the Environment Deep eutectic solvents General Chemistry 021001 nanoscience & nanotechnology 3. Good health 030104 developmental biology Biochemistry Chemical engineering 13. Climate action 0210 nano-technology |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| ISSN: | 2168-0485 |
| DOI: | 10.1021/acssuschemeng.7b01707 |
| Popis: | Recent findings have reported the reason why some living beings are able to withstand the huge thermal amplitudes between winter and summer in their natural habitats. They are able to produce metabolites decreasing deeply the crystallization temperature of water, avoiding cell disrupture due to the presence of ice crystals and overcoming osmotic effects. In vitro, the possibility to cool living cells and tissues to cryogenic temperatures in the absence of ice can be achieved through a vitrification process. Vitrification has been suggested as an alternative approach to cryopreservation and could hereafter follow an interesting biomimetic perspective. The metabolites produced by these animals are mostly sugars, organic acids, choline derivatives, or urea. When combined at a particular composition, these compounds form a new liquid phase which has been defined as Natural Deep Eutectic Solvents (NADES). In this review, we relate the findings of different areas of knowledge from evolutive biology, cryobiology, and thermodynamics and give a perspective to the potential of NADES in the development of new cryoprotective agents. The authors gratefully acknowledge the financial support of FCT through the project Des.zyme - Biocatalytic separation of enantiomers using Natural Deep Eutectic Solvents (PTDC/ BBB-EBB/1676/2014). The funding received from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement numbers REGPOT-CT2012-316331- POLARIS, as well as from European Regional Development Fund (ERDF) under the project “Novel smart and biomimetic materials for innovative regenerative medicine approaches” RL1- ABMR-NORTE-01-0124-FEDER-000016), cofinanced by North Portugal Regional Operational Programme (ON.2, O Novo Norte), under the National Strategic Reference Framework (NSRF), are also appreciatively acknowledged. info:eu-repo/semantics/publishedVersion |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|