Design, Synthesis, and Biological Activity of Chalcone Analogs Containing 4‐Phenylquinolin and Benzohydrazide

Autor:	Qiu‐Wan Tan, Li‐Ya He, Shan‐Shan Zhang, Zhi‐Wen He, Wei‐Hua Liu, Li Zhang, Li‐Ping Guan, Si‐Hong Wang
Rok vydání:	2022
Předmět:	Molecular Structure Anti-Inflammatory Agents Bioengineering General Chemistry General Medicine Biochemistry Molecular Docking Simulation Mice Structure-Activity Relationship Chalcone Chalcones Animals Molecular Medicine Molecular Biology
Zdroj:	Chemistry & Biodiversity. 19
ISSN:	1612-1880 1612-1872
DOI:	10.1002/cbdv.202100610
Popis:	A series of chalcone derivatives (3a-3m) containing 4-phenylquinoline and benzohydrazide were designed and synthesized, and their anti-inflammatory, analgesic, and antidepressant activities were evaluated. Using the classic antidepressant model, except for compounds 3a and 3d, 11 compounds all showed certain antidepressant activity at a dose of 100 mg/kg, among which compounds 3f, 3h, and 3m showed good antidepressant activity (inhibition rate, respectively 63.0 %, 73.2 %, and 76.4 %), which was equivalent to the positive control fluoxetine (inhibition rate of 70.0 %). Secondly, the inhibitory activity of these compounds on mouse MAO
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b139d7f9d714935a6614f054bbb369f0 https://doi.org/10.1002/cbdv.202100610 Zobrazit plný text záznamu Plný text