Sources of Reactive Oxygen and Nitrogen Species in Tissue Microenvironment of Hernioplasty Materials
| Autor: | N. N. Sarbaeva, M. N. Milyakova, O. V. Gribkova, Yu. V. Ponomareva |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Male Neutrophils Radical chemistry.chemical_element Polypropylenes Oxygen General Biochemistry Genetics and Molecular Biology Nitric oxide 03 medical and health sciences chemistry.chemical_compound Implants Experimental Materials Testing Animals Outbred Strains Cell Adhesion Macrophage Animals Reactive nitrogen species Herniorrhaphy Peroxidase chemistry.chemical_classification Titanium Reactive oxygen species Superoxide Macrophages General Medicine Surgical Mesh Reactive Nitrogen Species Rats 030104 developmental biology chemistry Immunology Biophysics Female Reactive Oxygen Species |
| Zdroj: | Bulletin of experimental biology and medicine. 161(5) |
| ISSN: | 1573-8221 |
| Popis: | Titanium and polypropylene mesh endoprostheses were implanted into the rat abdominal cavity and the populations of cells migrating to their surface were analyzed. On both materials, the cells were presented mainly by macrophages that proliferated, activated, and fused to form multinuclear cells. Contact with the foreign surface triggered superoxide anion generation and myeloperoxidase synthesis by macrophages (these processes were more intense on polypropylene implants than on titanium ones) and stimulated production of nitric oxide by macrophage. It was hypothesized that the effects of free nitrogen and oxygen radicals lead to oxidation and destruction of the polypropylene endoprosthesis surface. |
| Databáze: | OpenAIRE |
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