| Popis: |
Alcohol related health challenges have lingered over the years. Such associated with locally brewed alcoholic beverages have received little attention. The urgency to explore this becomes imperative. This study aimed at evaluating the effect of regular consumption of local alcoholic beverages on the estrous cycle and histological image of the ovaries and uterus thus fertility of female albino rats. Thirty screened female albino rats weighing 180-220g were divided into five groups and daily administered each with 10ml/kg ofpito,burukutu,ogogoro,goskolo and0.5ml/kg normal saline respectively for 21 days. Effect of the beverages on the estrous cycle as well as histopathological evaluation was carried out on the isolated ovaries and uterus. Results showed significant increase proestrous phase of the estrous cycle with ingestion ofpito, burukutu,ogogorogoandgoskolo. Also the histology of the ovary was basically without obvious pathological changes withpito, while there was alteration of histological parameters byburukutu,marked with formation of fibrosis, corpus luteum cyst resulting immature ovarian follicle,ogogoromarked with formation of fibrosis, corpus luteum cyst resulting immature ovarian follicle andgoskolomarked with formation of multiple follicular cyst resulting in complete collapse of the ovarian section. The effect of traditional alcoholic beverages revealed the classical effects of alcoholic drinks by way of significant alteration in the estrous cycle of albino rats with marked alteration of the histological architecture of ovarian tissues.Pito,burukutu,ogogoro, andgoskolohave a reprotoxic effect on the ovaries and uterus thus a deleterious effect on fertility of female albino rats. |
