SLX4 gains weight with SUMO in genome maintenance
| Autor: | Pierre-Henri L. Gaillard, Jean-Hugues Guervilly |
|---|---|
| Přispěvatelé: | gaillard, pierre-henri, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Cancer Research [SDV.CAN]Life Sciences [q-bio]/Cancer SUMO binding [SDV.BC]Life Sciences [q-bio]/Cellular Biology Computational biology Biology medicine.disease_cause 03 medical and health sciences [SDV.CAN] Life Sciences [q-bio]/Cancer Fanconi anemia Genome maintenance DNA Repair Protein [SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular Biology medicine [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Author's View [SDV.BC] Life Sciences [q-bio]/Cellular Biology Genetics Replication stress medicine.disease 030104 developmental biology Cancer cell Molecular Medicine Signal transduction Carcinogenesis |
| Zdroj: | Molecular & Cellular Oncology Molecular & Cellular Oncology, 2016, 3, pp.e1008297. ⟨10.1080/23723556.2015.1008297⟩ Molecular & Cellular Oncology, Taylor et Francis, 2016, 3, pp.e1008297. ⟨10.1080/23723556.2015.1008297⟩ |
| ISSN: | 2372-3556 |
| Popis: | International audience; Replication stress has emerged as a key driver of oncogenesis but also represents an Achilles’ heel of cancer cells. Newly reported SUMO binding and SUMO ligase functions of the DNA repair SLX4 protein that impact the outcome of replication stress open new avenues for investigating roles played by SLX4 in tumorigenesis. |
| Databáze: | OpenAIRE |
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