Streptozotocin Treatment of Streptozotocin-lnduced Islet Cell Adenomas in Rats
| Autor: | N, Rakieten, B S, Gordon, A, Beaty, R W, Bates, P S, Schein, F G, Standaert |
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| Rok vydání: | 1976 |
| Předmět: |
Blood Glucose
Niacinamide medicine.medical_specialty Nicotinamide business.industry Antitumor response Islet Cell Adenoma Pharmacology Adenoma Islet Cell Streptozotocin medicine.disease Malignant insulinoma Streptozocin General Biochemistry Genetics and Molecular Biology Rats chemistry.chemical_compound Endocrinology chemistry Internal medicine Animals Insulin Medicine Neoplasm business medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 151:632-635 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-151-39275 |
| Popis: | SummaryHypoglycemic rats bearing insulin-secreting islet-cell adenomas produced by the combined action of streptozotocin and nicotinamide were treated with streptozotocin. Antitumor response was demonstrated by elevation of blood glucose, reduction in plasma and tumor IRI, and histo-pathologic changes in the beta-cell neoplasm. The rodent tumor model may serve as a predictive system for selection and investigation of mechanisms of action of future antitumor agents to be used in the treatment of malignant insulinoma in man.The authors gratefully acknowledge the many helpful suggestions of Dr. David A. Cooney and Mrs. Ruth D. Davis of the Laboratory of Toxicology, DCT, NCI, without whose extended cooperation these studies would not have been initiated or completed; and Marie Gottlieb and Elizabeth Perry for valuable technical assistance. |
| Databáze: | OpenAIRE |
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