Roles of the bed nucleus of the stria terminalis and amygdala in fear reactions
| Autor: | Hulsman, A.M., Terburg, D., Roelofs, K., Klumpers, F., Swaab, D.F., Kreier, F., Lucassen, P.J., Salehi, A., Buijs, R.M. |
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| Přispěvatelé: | Swaab, D.F., Kreier, F., Lucassen, P.J., Salehi, A., Buijs, R.M. |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Handbook of Clinical Neurology ISBN: 9780128199756 Swaab, D.F.; Kreier, F.; Lucassen, P.J. (ed.), Handbook of clinical neurology. Vol. 179: The human hypothalamus: Anterior region, 419-432. San Diego : Elsevier STARTPAGE=419;ENDPAGE=432;TITLE=Swaab, D.F.; Kreier, F.; Lucassen, P.J. (ed.), Handbook of clinical neurology. Vol. 179: The human hypothalamus: Anterior region Swaab, D.F.; Kreier, F.; Lucassen, P.J. (ed.), Handbook of clinical neurology. Vol. 179: The human hypothalamus: Anterior region, pp. 419-432 |
| Popis: | Item does not contain fulltext The bed nucleus of the stria terminalis (BNST) plays a critical modulatory role in driving fear responses. Part of the so-called extended amygdala, this region shares many functions and connections with the substantially more investigated amygdala proper. In this chapter, we review contributions of the BNST and amygdala to subjective, behavioral, and physiological aspects of fear. Despite the fact that both regions are together involved in each of these aspects of fear, they appear complimentary in their contributions. Specifically, the basolateral amygdala (BLA), through its connections to sensory and orbitofrontal regions, is ideally poised for fast learning and controlling fear reactions in a variety of situations. The central amygdala (CeA) relies on BLA input and is particularly important for adjusting physiological and behavioral responses under acute threat. In contrast, the BNST may profit from more extensive striatal and dorsomedial prefrontal connections to drive anticipatory responses under more ambiguous conditions that allow more time for planning. Thus current evidence suggests that the BNST is ideally suited to play a critical role responding to distant or ambiguous threats and could thereby facilitate goal-directed defensive action. |
| Databáze: | OpenAIRE |
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