Proton pump inhibitors use and risk of chronic kidney disease and end-stage renal disease
| Autor: | Paulo Roberto Bignardi, Vinicius Daher Alvares Delfino, Carolina Santos Vengrus |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Databases Factual business.industry Urology Proton Pump Inhibitors Disease Cochrane Library urologic and male genital diseases medicine.disease female genital diseases and pregnancy complications Confidence interval End stage renal disease Clinical trial Nephrology Internal medicine Relative risk medicine Odds Ratio Humans Kidney Failure Chronic Observational study Renal Insufficiency Chronic business Kidney disease |
| Zdroj: | Minerva urology and nephrology. 73(4) |
| ISSN: | 2724-6442 |
| Popis: | INTRODUCTION A possible association between long-term proton pump inhibitors (PPI) use and chronic kidney disease (CKD) has been recently described. Due to the potential health risk of this association, in the absence of proper clinical trials, we have decided to carry out a systematic review followed by meta-analysis. EVIDENCE ACQUISITION PubMed, Cochrane Library, and Lilacs databases were searched. Studies that reported an association between PPI use and CKD or End-stage Renal Disease (ESRD) published until December 23, 2019, were included. All selected studies present high quality according to the New-Castle-Ottawa. The risk ratio (RR) and confidence interval (CI) were pooled using a random-effects model in CKD outcome analysis and fixed effects model for ESRD. A total of 10 observational studies were selected. EVIDENCE SYNTHESIS Compared to patients who did not use PPI, the RR for CKD associated with PPI use was 1.35 (95% CI 1.15-1.56) with P |
| Databáze: | OpenAIRE |
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