Improved Glucose Profile in Patients With Type 2 Diabetes With a New, High-Protein, Diabetes-Specific Tube Feed During 4 Hours of Continuous Feeding
| Autor: | Stefano Genovese, Antonio Ceriello, Zandrie Hofman, Mirian Lansink, Carlette H.F.C. Rouws |
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| Rok vydání: | 2016 |
| Předmět: |
Blood Glucose
Dietary Fiber Male 0301 basic medicine medicine.medical_specialty medicine.medical_treatment Medicine (miscellaneous) Type 2 diabetes Body Mass Index 03 medical and health sciences Enteral Nutrition Double-Blind Method Diabetes mellitus Internal medicine Dietary Carbohydrates medicine Humans Insulin In patient Aged Food Formulated Glycated Hemoglobin Cross-Over Studies 030109 nutrition & dietetics Nutrition and Dietetics business.industry Continuous feeding Middle Aged medicine.disease Dietary Fats Crossover study Diet Endocrinology Parenteral nutrition Diabetes Mellitus Type 2 Gastrointestinal Absorption Sample Size Diet High-Protein Female Dietary Proteins business Body mass index |
| Zdroj: | Journal of Parenteral and Enteral Nutrition. 41:968-975 |
| ISSN: | 1941-2444 0148-6071 |
| DOI: | 10.1177/0148607115625635 |
| Popis: | Hyperglycemia frequently occurs in hospitalized patients receiving nutrition support. In this study, the effects of a new diabetes-specific formula (DSF) on glucose profile during 4 hours of continuous feeding and 4 hours after stopping feeding were compared with a standard formula (SF).In this randomized, controlled, double-blind, crossover study, ambulant, nonhospitalized patients with type 2 diabetes received the DSF or an isocaloric, fiber-containing SF via a nasogastric tube. After overnight fasting, the formula was continuously administered to the patients during 4 hours. Plasma glucose and insulin concentrations were determined during the 4-hour period and in the subsequent 4 hours during which no formula was provided.During the 4-hour feeding period, DSF compared with SF resulted in a lower mean delta glucose concentration in the 3- to 4-hour period (0.3 ± 1.0 and 2.4 ± 1.5 mmol/L; P.001). Also, the (delta) peak concentrations, (delta) mean concentrations, and incremental area under the curve (iAUC) for glucose and insulin were significantly lower during DSF compared with SF feeding (all comparisons: P.001). Furthermore, fewer patients experienced hyperglycemia (10 mmol/L) on DSF compared with SF (2 vs 11, P = .003, respectively). No differences in number of patients with hypoglycemia (3.9 mmol/L) were observed. No significant differences in tolerance were observed.Administration of a new, high-protein DSF during 4 hours of continuous feeding resulted in lower glucose and insulin levels compared with a fiber-containing SF in ambulant, nonhospitalized patients with type 2 diabetes. These data suggest that a DSF may contribute to lower glucose levels in these patients. |
| Databáze: | OpenAIRE |
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