Discrete stages of human intrathymic differentiation: Analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage
| Autor: | Raphael H. Levey, Ellis L. Reinherz, Stuart F. Schlossman, Patrick C. Kung, Gideon Goldstein |
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| Rok vydání: | 1980 |
| Předmět: |
Antibodies
Neoplasm T-Lymphocytes T cell Cellular differentiation Population Thymus Gland Biology Antigen Antigens Neoplasm Isoantibodies medicine Humans Cytotoxic T cell education education.field_of_study Multidisciplinary Lymphoblast Cell Differentiation Molecular biology Clone Cells Leukemia Lymphoid Thymocyte medicine.anatomical_structure Antigens Surface Immunology Common Thymocyte Biological Sciences: Immunology |
| Zdroj: | Proceedings of the National Academy of Sciences. 77:1588-1592 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.77.3.1588 |
| Popis: | A series of monoclonal antibodies was used to define three discrete stages of human intrathymic T-cell differentiation. The earliest stage was confined to + , OKT5 + , OKT6 + “common” thymocyte population represents the majority of thymocytes and accounts for more than 70% of thymocytes. With further maturation, thymocytes lose OKT6 reactivity, segregate into OKT4 + and OKT5 + subsets, and acquire reactivity with OKT3 (and OKT1). This latter stage corresponds to the more functionally mature subset. The possible relationship of acute lymphoblastic leukemia of T-cell lineage to these proposed stages of intrathymic differentiation was determined. Analysis of 25 tumor populations showed that 21 could be related to one or another differentiative stage. The majority (15/21) were derived from an early thymocyte or prothymocyte subpopulation, 5/25 were derived from a common thymocyte subpopulation, and 1/25 was derived from a mature (OKT3 + ) subpopulation. These data suggest that is it now possible to define stages of T-cell differentiation that can be related to T-cell malignancies in humans. |
| Databáze: | OpenAIRE |
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