Plasma uptake of selected phenolic acids following New Zealand blackcurrant extract supplementation in humans
| Autor: | Karen M. Keane, Ben J. Lee, Nathan A. Lewis, Sam D. Blacker, Stephen D. Myers, Rianne Costello, Fiona A. Myers, Mark E. T. Willems |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
0301 basic medicine
Adult Male B400 High-performance liquid chromatography Protocatechuic acid Anthocyanins 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Ribes Gallic Acid Vanillic acid Humans Pharmacology (medical) Gallic acid Food science 030109 nutrition & dietetics Nutrition and Dietetics Plant Extracts 030229 sport sciences Venous blood QP Bioavailability chemistry Polyphenol Anthocyanin Dietary Supplements Female Food Science New Zealand RC |
| ISSN: | 1939-0211 |
| Popis: | New Zealand blackcurrant (NZBC) extract is a rich source of anthocyanins and in order to exert physiological effects, the anthocyanin-derived metabolites need to be bioavailable in vivo. We examined the plasma uptake of selected phenolic acids following NZBC extract supplementation alongside maintaining a habitual diet (i.e. not restricting habitual polyphenol intake). Twenty healthy volunteers (nine females, age: 28 ± 7 years, height 1.73 ± 0.09 m, body mass 73 ± 11 kg) consumed a 300 mg NZBC extract capsule (CurraNZ®; anthocyanin content 105 mg) following an overnight fast. Venous blood samples were taken pre and 1, 1.5, 2, 3, 4, 5, and 6 h post-ingestion of the capsule. Reversed-phase high-performance liquid chromatography (HPLC) was used for analysis of two dihydroxybenzoic acids [i.e. vanillic acid (VA) and protocatechuic acid (PCA)] and one trihydroxybenzoic acid [i.e. gallic acid (GA)] in plasma following NZBC extract supplementation. Habitual anthocyanin intake was 168 (95%CI:68–404) mg⋅day−1 and no associations were observed between this and VA, PCA, and GA plasma uptake by the NZBC extract intake. Plasma time-concentration curves revealed that GA, and PCA were most abundant at 4, and 1.5 h post-ingestion, representing a 261% and 320% increase above baseline, respectively, with VA remaining unchanged. This is the first study to demonstrate that an NZBC extract supplement increases the plasma uptake of phenolic acids GA, and PCA even when a habitual diet is followed in the days preceding the experimental trial, although inter-individual variability is apparent. |
| Databáze: | OpenAIRE |
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