Expression Analysis of SOCS Genes in Migraine
| Autor: | Mohammad Samadian, Mohammad Taheri, Kasra Honarmand Tamizkar, Arezou Sayad, Soudeh Ghafouri-Fard |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
without aura Aura business.industry Healthy subjects Neurosciences. Biological psychiatry. Neuropsychiatry Venous blood medicine.disease SOCS Gastroenterology Cellular and Molecular Neuroscience aura Migraine Internal medicine expression Expression analysis SOCS5 Medicine migraine In patient business Molecular Biology Gene RC321-571 |
| Zdroj: | Frontiers in Molecular Neuroscience, Vol 14 (2021) |
| ISSN: | 1662-5099 |
| DOI: | 10.3389/fnmol.2021.725048 |
| Popis: | Migraine is a complex neurological condition affecting a large proportion of persons. Dysregulation of several immune-related transcripts has been noted in migraineurs suggesting an immune-based background for this condition. We measured expression levels suppressor of cytokine signaling (SOCS) genes in the venous blood of migraineurs compared with controls. SOCS1 was down-regulated in patients without aura compared with controls [Ratio of mean expression (RME) = 0.08, P value < 0.001]. This pattern was also detected among female subgroups (RME = 0.06, P value = 0.010), but not among male subgroups (RME = 0.22, P value = 0.114). Expression of SOCS1 was significantly higher in patients with aura compared with those without aura (RME = 5.89, P value = 0.037). Meanwhile, expression of SOCS2 was lower in migraineurs with aura compared with controls (RME = 0.03, P value < 0.001). In addition, this gene was under-expressed in patients without aura compared with controls and in both sex-based subgroups of this group of patients (RME = 0.01, P value < 0.001 for all comparisons). However, its expression was higher in male patients with aura compared with those without aura (P value < 0.001). For SOCS3, we detected a lower level of expression in patients without aura compared with controls (RME = 0.07, P value < 0.001). However, the expression of SOCS3 was higher in patients with aura compared with those without aura (RME = 7.46, P value = 0.001). SOCS5 was down-regulated in patients without aura compared with controls (RME = 0.10, P value < 0.001). Expression of this gene was also lower in patients with aura compared with controls (RME = 0.03, P value < 0.001), and in male patients of this group compared with controls (RME = 0.03, P value = 0.004). On the other hand, expression of SOCS5 was higher in male patients with aura compared with sex-matched patients without aura (RME = 6.67, P value = 0.001). SOCS2 levels could appropriately differentiate migraineurs from healthy subjects. The current study suggests the role of SOCS genes in the pathoetiology of migraine. |
| Databáze: | OpenAIRE |
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