Multicenter study of quantitative computed tomography analysis using a computer-aided three-dimensional system in patients with idiopathic pulmonary fibrosis
| Autor: | Tae Iwasawa, Toshiyuki Gotoh, Tetsu Kanauchi, Tomohisa Baba, Takashi Ogura, Toshiko Hoshi, Mari S. Oba |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Vital capacity medicine.medical_specialty Multivariate analysis 030218 nuclear medicine & medical imaging 03 medical and health sciences FEV1/FVC ratio Idiopathic pulmonary fibrosis Imaging Three-Dimensional 0302 clinical medicine Histogram Humans Medicine Radiology Nuclear Medicine and imaging Prospective Studies Quantitative computed tomography Prospective cohort study Lung Aged Aged 80 and over medicine.diagnostic_test business.industry Middle Aged medicine.disease Idiopathic Pulmonary Fibrosis 030228 respiratory system Feasibility Studies Female Radiology Tomography X-Ray Computed business Kappa |
| Zdroj: | Japanese Journal of Radiology. 34:16-27 |
| ISSN: | 1867-108X 1867-1071 |
| DOI: | 10.1007/s11604-015-0496-0 |
| Popis: | To evaluate the feasibility of automated quantitative analysis with a three-dimensional (3D) computer-aided system (i.e., Gaussian histogram normalized correlation, GHNC) of computed tomography (CT) images from different scanners. Each institution’s review board approved the research protocol. Informed patient consent was not required. The participants in this multicenter prospective study were 80 patients (65 men, 15 women) with idiopathic pulmonary fibrosis. Their mean age was 70.6 years. Computed tomography (CT) images were obtained by four different scanners set at different exposures. We measured the extent of fibrosis using GHNC, and used Pearson’s correlation analysis, Bland–Altman plots, and kappa analysis to directly compare the GHNC results with manual scoring by radiologists. Multiple linear regression analysis was performed to determine the association between the CT data and forced vital capacity (FVC). For each scanner, the extent of fibrosis as determined by GHNC was significantly correlated with the radiologists’ score. In multivariate analysis, the extent of fibrosis as determined by GHNC was significantly correlated with FVC (p |
| Databáze: | OpenAIRE |
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