Mutations in CCR5-Coding Sequences Are Not Associated with SIV Carrier Status in African Nonhuman Primates
| Autor: | Anders Fomsgaard, Françoise Barré-Sinoussi, Ousmane M. Diop, Jan Hansen, Jacques Rigoulet, Marie-Claude Georges-Courbot, Sylvie Corbet, Michaela Müller-Trutwin |
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| Rok vydání: | 1999 |
| Předmět: |
Primates
Cercopithecus ascanius Pan troglodytes Receptors CCR5 animal diseases Molecular Sequence Data Immunology Simian Acquired Immunodeficiency Syndrome Cercopithecus medicine.disease_cause Cercopithecus aethiops Virology medicine Animals Humans Amino Acid Sequence Phylogeny Cercopithecus nictitans Sequence Homology Amino Acid biology Cercopithecus neglectus virus diseases Simian immunodeficiency virus biology.organism_classification Cercocebus galeritus Infectious Diseases Carrier State Mutation Lentivirus Cercopithecus cephus Simian Immunodeficiency Virus |
| Zdroj: | AIDS Research and Human Retroviruses. 15:931-939 |
| ISSN: | 1931-8405 0889-2229 |
| Popis: | African monkeys can be naturally infected with SIV but do not progress to AIDS. Since mutations in the human CCR5 gene have been shown to influence susceptibility to HIV infection and disease progression, we have now investigated whether mutations in CCR5-coding sequences in African nonhuman primates can explain species-specific differences in susceptibility to lentiviral infection. The animals studied comprise chronically infected monkeys corresponding to four natural hosts of SIV (Cercopithecus aethiops, Cercopithecus pygerythrus, Cercopithecus sabaeus, and Cercopithecus tantalus), noninfected animals from three species that are known to be susceptible to SIV infection (Cercopithecus patas, Cercopithecus Ihoesti, and Pan troglodytes), and monkeys of six species that do not carry SIV in the wild (Cercocebus galeritus, Cercocebus aterrimus, Cercopithecus ascanius, Cercopithecus nictitans, Cercopithecus neglectus, and Cercopithecus cephus). We observed a high degree of genetic divergence among the species. The rate of accumulation of amino acid mutations was, however, not higher in SIV carriers than in other nonhuman primates. No homozygous premature stop codons, deletions, or frameshift mutations were detected. In at least two animals, one infected AGM (Cercopithecus tantalus) and one noninfected monkey (Cercocebus aterrimus), the CCR5 alleles identified encode functional proteins, as they were identical in terms of amino acid sequence to that of functional CCR5 reported in the literature. We found no other consistent differences in the genetic variability of CCR5-coding sequences between the nonhuman primates that are carriers of SIV and those that are not. |
| Databáze: | OpenAIRE |
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