Cardioprotective Activity of 2,6-Diisobornyl-4-Methylphenol in Acute Myocardial Ischemia/Reperfusion in Rats
| Autor: | Galina A. Chernysheva, I Yu Chukicheva, Mark B. Plotnikov, Pyotr P. Shchetinin, A. V. Kuchin, T. M. Plotnikova, V A Smol'yakova |
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| Rok vydání: | 2018 |
| Předmět: |
Boron Compounds
Male medicine.medical_specialty Cardiotonic Agents Myocardial ischemia Myocardial Infarction Ischemia Infarction Myocardial Reperfusion Injury 030204 cardiovascular system & hematology Necrotic Change 01 natural sciences Antioxidants Drug Administration Schedule General Biochemistry Genetics and Molecular Biology Cresols 03 medical and health sciences 0302 clinical medicine Heart Rate Internal medicine Animals Medicine cardiovascular diseases Rats Wistar Survival rate Gastric Absorption 010405 organic chemistry business.industry General Medicine medicine.disease Coronary Vessels Survival Analysis Rats 0104 chemical sciences Coronary Occlusion Cardiology business Anti-Arrhythmia Agents |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 165:657-659 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-018-4235-2 |
| Popis: | We studied the cardioprotective effect of 2,6-diisobornyl-4-methylphenol under conditions of myocardial ischemia/reperfusion in rats. Daily administration of 2,6-diisobornyl-4-methylphenol (100 mg/kg intragastrically) over 3 days before and 5 days after modeling of myocardial ischemia/reperfusion prevented the increase in the infarction area by almost 2 times in comparison with the control by day 5 after recirculation. The type and severity of pathological changes in ECG parameters reflecting necrotic changes in the myocardium under the action of the compound significantly decreased by day 35 of the experiment. Animal survival rate during the first 24 h after ischemia/reperfusion modeling in the experimental group was by 29% higher than in the control group. |
| Databáze: | OpenAIRE |
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