Targeted destruction of cancer stem cells using multifunctional magnetic nanoparticles that enable combined hyperthermia and chemotherapy
| Autor: | Mengsu Yang, Siu-Kie Au, Yu Zhu, Shubin Wang, Dandan Liu, Yingcai Hong, Tak-Chun Yip, Yaping Li, Chi-Chun Fong, Weimao Wang, Chong Hu, Wai-Kin Yu |
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| Rok vydání: | 2019 |
| Předmět: |
Hyperthermia
Lung Neoplasms medicine.medical_treatment Medicine (miscellaneous) Mice Nude Antineoplastic Agents 02 engineering and technology Metastasis Multifunctional nanoparticle 03 medical and health sciences Mice In vivo Cancer stem cell Cell Line Tumor medicine Animals Humans Lung cancer stem cell Magnetite Nanoparticles Pharmacology Toxicology and Pharmaceutics (miscellaneous) Thermotherapy and chemotherapy 030304 developmental biology 0303 health sciences Chemotherapy Drug Carriers Mice Inbred BALB C Alternating magnetic field business.industry Mesenchymal Stem Cells Hyperthermia Induced 021001 nanoscience & nanotechnology medicine.disease Combined Modality Therapy Small Cell Lung Carcinoma In vitro Cancer research Neoplastic Stem Cells Magnetic nanoparticles Nanomedicine Neoplasm Recurrence Local 0210 nano-technology business Research Paper |
| Zdroj: | Theranostics |
| ISSN: | 1838-7640 |
| Popis: | Cancer stem cells (CSCs) have been implicated in cancer recurrence and therapy resistance. Therefore, a CSC-targeted therapy that disrupts the maintenance and survival of CSCs may offer an effective approach in killing tumor cells in primary tumors and preventing the metastasis caused by CSCs. Nanoparticles (NPs)-based thermotherapy and/or chemotherapy are promising therapeutic methods for cancer treatment. Methods: A silica-based multifunctional NP system was present, which encapsulated a chemotherapeutic agent and magnetic cores and coated with a specific antibody against the lung CSCs. The efficacy of this novel therapeutic strategy was systematically studied both in vitro and in vivo by simultaneous activating the combined thermotherapy and chemotherapy via CSC-targeted NPs. Results: These NPs were systematically administered and activated for targeted chemotherapy and thermotherapy by using an externally applied alternating magnetic field (AMF). The antibody-modified NPs targeted to lung CSCs with enhanced cellular uptake in vitro and extended accumulation in tumor in vivo. Up to 98% of lung CSCs was killed in vitro with 30-min application of AMF, due to the combined effects of hyperthermia and chemotherapeutic drug treatment. In in vivo models, this combined therapy significantly suppressed tumor growth and metastasis in lung CSC xenograft-bearing mice, with minimal side effects and adverse effects. Conclusion: With good biocompatibility and targeting capability, the nanodrug delivery system may offer a promising clinical platform for the combined thermotherapy and chemotherapy. This work demonstrated the feasibility of developing multifunctional nanomedicine targeting CSCs for effective cancer treatment. |
| Databáze: | OpenAIRE |
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