Primary progressive multiple sclerosis: increasing clarity but many unanswered questions
| Autor: | G.V McDonnell, Stanley Hawkins |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Population Primary Progressive Multiple Sclerosis Disease law.invention Diagnosis Differential Primary progressive law medicine Humans education Intensive care medicine Pathological education.field_of_study business.industry Multiple sclerosis Clinical course Multiple Sclerosis Chronic Progressive Prognosis medicine.disease Magnetic Resonance Imaging Neurology CLARITY Controlled Clinical Trials as Topic Neurology (clinical) business Neuroscience Immunosuppressive Agents |
| Zdroj: | Journal of the Neurological Sciences. 199:1-15 |
| ISSN: | 0022-510X |
| Popis: | Heterogeneity in the clinical course of multiple sclerosis (MS) is well recognised and patients following a primary progressive course, 10-15% of the MS population, have a distinct clinical and paraclinical phenotype. This review examines recent advances in our understanding of this subgroup of patients and examines the new criteria to be applied in diagnosis. It also highlights developments in genetic, immunological, magnetic resonance and pathological aspects of the disease, whilst also outlining the results of recent therapeutic trials. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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