Treatment with high doses of anti-IgM prevents, but with lower doses accelerates autoimmune disease in (NZW x BXSB)F1 hybrid mice
| Autor: | Cerny, A., Starobinski, M., Hugin, A. W., Sutter, S., Zinkernagel, R. M., Izui, Shozo |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
B-Lymphocytes Autoimmune Diseases/genetics/immunology/ therapy Immunology B-Lymphocytes/immunology Mice Inbred Strains ddc:616.07 Mice Mutant Strains Mice Mutant Strains/genetics/immunology Antibodies Anti-Idiotypic Autoimmune Diseases Mice Lupus Erythematosus Systemic/genetics/immunology/ therapy Immunoglobulin M immune system diseases Immunology and Allergy Animals Hybridization Genetic Lupus Erythematosus Systemic Female Mice Inbred Strains/genetics/immunology Antibodies Anti-Idiotypic/administration & dosage/ therapeutic use skin and connective tissue diseases Immunoglobulin M/administration & dosage/ therapeutic use |
| Zdroj: | Journal of Immunology, Vol. 138, No 12 (1987) pp. 4222-4228 |
| ISSN: | 0022-1767 |
| Popis: | We have treated autoimmune-prone (NZW x BXSB)F1 hybrid mice with polyclonal rabbit anti-mouse IgM antibodies starting from birth to define conditions leading to quantitative and functional elimination of the B cell compartment and to determine the effect of anti-IgM treatment on the development of autoimmune disease. A maintenance dose of anti-IgM antibodies (600 micrograms/wk), which efficiently induced B cell depletion in various non-autoimmune strains of mice, was not sufficient to deplete B cells from autoimmune-prone (NZW x BXSB)F1 mice. (NZW x BXSB)F1 mice required approximately twice as many anti-IgM antibodies (1200 micrograms/wk) to maintain the suppression of B cell development. Continuous treatment with the sub-suppressive dose of anti-IgM antibodies led to a marked acceleration of autoimmune disease in (NZW x BXSB)F1 mice. In contrast, elimination of B cells in (NZW x BXSB)F1 mice with a higher dose of anti-IgM antibodies (1200 micrograms/wk) completely prevented autoantibody production, immune complex formation, and development of glomerulonephritis and vascular lesions associated with mononuclear cell infiltrations. Our results are a direct demonstration of the primary role of autoantibodies for the development of various tissue lesions seen in systemic lupus erythematosus (SLE) and indicates that autoreactive effector T cells, if they exist, play no major direct role in the pathogenesis of SLE, at least in (NZW x BXSB)F1 hybrid mice. |
| Databáze: | OpenAIRE |
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