Cellular Self-Digestion and Persistence in Bacteria
| Autor: | Prashant Karki, Shayne Sensenbach, Vahideh Angardi, Mehmet A. Orman, Han G Ngo, Sayed Golam Mohiuddin, Narendra K. Dewangan, Sreyashi Ghosh |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Proteases autophagy QH301-705.5 Review Protein degradation Microbiology Persistence (computer science) stationary-phase metabolism RNA degradation Virology Extracellular Biology (General) intracellular degradation chemistry.chemical_classification biology Autophagy biology.organism_classification viable but non-culturable cells Cell biology self-digestion bacterial persisters Enzyme chemistry protein degradation lipid degradation Bacteria Intracellular |
| Zdroj: | Microorganisms Microorganisms, Vol 9, Iss 2269, p 2269 (2021) |
| ISSN: | 2076-2607 |
| Popis: | Cellular self-digestion is an evolutionarily conserved process occurring in prokaryotic cells that enables survival under stressful conditions by recycling essential energy molecules. Self-digestion, which is triggered by extracellular stress conditions, such as nutrient depletion and overpopulation, induces degradation of intracellular components. This self-inflicted damage renders the bacterium less fit to produce building blocks and resume growth upon exposure to fresh nutrients. However, self-digestion may also provide temporary protection from antibiotics until the self-digestion-mediated damage is repaired. In fact, many persistence mechanisms identified to date may be directly or indirectly related to self-digestion, as these processes are also mediated by many degradative enzymes, including proteases and ribonucleases (RNases). In this review article, we will discuss the potential roles of self-digestion in bacterial persistence. |
| Databáze: | OpenAIRE |
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