Role of calcitonin gene-related peptide and capsaicin-sensitive afferents in central thyrotropin-releasing hormone-induced hepatic hyperemia
| Autor: | Toru Kono, Shiro Yokohama, Kimihide Nakamura, Keisuke Tamori, Isao Makino, Akira Terano, Masashi Yoneda, Yoichi Sato |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Time Factors Calcitonin Gene-Related Peptide Thyrotropin-releasing hormone Neuropeptide Hyperemia Stimulation Calcitonin gene-related peptide Biology Peptide hormone chemistry.chemical_compound Internal medicine medicine Animals Humans Neurons Afferent Rats Wistar Thyrotropin-Releasing Hormone Pharmacology Serum Albumin Bovine Peptide Fragments Rats Endocrinology medicine.anatomical_structure Liver nervous system chemistry Regional Blood Flow Capsaicin Calcitonin Injections Intravenous Cattle hormones hormone substitutes and hormone antagonists Blood vessel |
| Zdroj: | European Journal of Pharmacology. 380:31-35 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/s0014-2999(99)00527-0 |
| Popis: | The involvement of capsaicin-sensitive afferent neurons and calcitonin gene-related peptide (CGRP) in the central thyrotropin-releasing hormone (TRH)-induced hepatic hyperemia was investigated in urethane anesthetized rats. Both systemic capsaicin pretreatment and intravenous administration of CGRP receptor antagonist, human CGRP-(8-37), completely abolished the stimulatory effect of hepatic blood flow induced by intracisternal injection of TRH analog (RX-77368; p-Glu-His-(3,3'-dimethyl)-Pro-NH2, 100 ng), assessed by the hydrogen gas clearance method. These data demonstrate the involvement of capsaicin-sensitive afferent neurons and CGRP in the central TRH-induced stimulation of hepatic blood flow. |
| Databáze: | OpenAIRE |
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