Image-guided adaptive radiotherapy in patients with locally advanced non-small cell lung cancer: the art of PET
| Autor: | Willem Grootjans, L. F. de Geus-Oei, Johan Bussink |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Lung Neoplasms medicine.medical_treatment 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Carcinoma Non-Small-Cell Lung medicine Medical imaging Carcinoma Humans Radiology Nuclear Medicine and imaging Lung cancer Adverse effect Chemotherapy medicine.diagnostic_test Radiotherapy business.industry Radiotherapy Planning Computer-Assisted Cancer medicine.disease Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] Radiation therapy Treatment Outcome non-small-cell lung Positron emission tomography 030220 oncology & carcinogenesis Radiology Positron-emission tomography business Radiotherapy Image-Guided Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] |
| Zdroj: | Quarterly Journal of Nuclear Medicine and Molecular Imaging, 62, 369-384 Quarterly Journal of Nuclear Medicine and Molecular Imaging, 62, 4, pp. 369-384 Quarterly Journal of Nuclear Medicine and Molecular Imaging, 62(4), 369-384 Quarterly Journal of Nuclear Medicine and Molecular Imaging |
| ISSN: | 1824-4785 |
| DOI: | 10.23736/S1824-4785.18.03084-4 |
| Popis: | Item does not contain fulltext With a worldwide annual incidence of 1.8 million cases, lung cancer is the most diagnosed form of cancer in men and the third most diagnosed form of cancer in women. Histologically, 80-85% of all lung cancers can be categorized as non-small cell lung cancer (NSCLC). For patients with locally advanced NSCLC, standard of care is fractionated radiotherapy combined with chemotherapy. With the aim of improving clinical outcome of patients with locally advanced NSCLC, combined and intensified treatment approaches are increasingly being used. However, given the heterogeneity of this patient group with respect to tumor biology and subsequent treatment response, a personalized treatment approach is required to optimize therapeutic effect and minimize treatment induced toxicity. Medical imaging, in particular positron emission tomography (PET), before and during the course radiotherapy is increasingly being used to personalize radiotherapy. In this setting, PET imaging can be used to improve delineation of target volumes, employ molecularly-guided dose painting strategies, early response monitoring, prediction and monitoring of treatment-related toxicity. The concept of PET image-guided adaptive radiotherapy (IGART) is an interesting approach to personalize radiotherapy for patients with locally advanced NSCLC, which might ultimately contribute to improved clinical outcomes and reductions in frequency of treatment-related adverse events in this patient group. In this review, we provide a comprehensive overview of available clinical data supporting the use of PET imaging for IGART in patients with locally advanced NSCLC. |
| Databáze: | OpenAIRE |
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