Exposure to polyfluoroalkyl chemicals during pregnancy is not associated with offspring age at menarche in a contemporary British cohort
| Autor: | Jon Heron, Mildred Maisonet, Carol Rubin, Antonia M. Calafat, W. Dana Flanders, Michele Marcus, Kayoko Kato, Michael A. McGeehin, Adrianne K. Holmes, Krista Y. Christensen |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Offspring Physiology Article Cohort Studies Young Adult chemistry.chemical_compound Pregnancy Humans Medicine Child lcsh:Environmental sciences General Environmental Science Menarche lcsh:GE1-350 Fluorocarbons business.industry Solid Phase Extraction medicine.disease United Kingdom Birth order Perfluorooctane Alkanesulfonic Acids chemistry Maternal Exposure Prenatal Exposure Delayed Effects Cohort Environmental Pollutants Female Caprylates Age of onset business Demography Cohort study |
| Zdroj: | Environment International, Vol 37, Iss 1, Pp 129-135 (2011) |
| ISSN: | 0160-4120 |
| Popis: | Introduction: Polyfluoroalkyl chemicals (PFCs) are commercially synthesized chemicals used in consumer products. Exposure to certain PFCs is widespread, and some PFCs may act as endocrine disruptors. We used data from the Avon Longitudinal Study of Parents and Children (ALSPAC) in the United Kingdom to conduct a nested case-control study examining the association between age at menarche, and exposure to PFCs during pregnancy. Methods: Cases were selected from female offspring in the ALSPAC who reported menarche before the age of 11.5 years (n=218), and controls were a random sample of remaining girls (n=230). Serum samples taken from the girls' mothers during pregnancy (1991–1992) were analyzed using on-line solid-phase extraction coupled to isotope dilution high-performance liquid chromatography-tandem mass spectrometry for 8 PFCs. Logistic regression was used to determine association between maternal serum PFC concentrations, and odds of earlier age at menarche. Results: PFOS and PFOA were the predominant PFCs (median serum concentrations of 19.8 ng/mL and 3.7 ng/mL). All but one PFC were detectable in most samples. Total PFC concentration varied by number of births (inverse association with birth order; p-value |
| Databáze: | OpenAIRE |
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