The effect of COVID-19 derived cytokine storm on cancer cells progression: double-edged sword
| Autor: | Mohammadjavad Mohammadtaghizadeh, Mehran Amrovani, Marziyeh Babazadeh, Mahboobeh Shojaei, Sadegh Abbasian, Mohammad Heydarian |
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| Rok vydání: | 2021 |
| Předmět: |
animal diseases
medicine.medical_treatment Drug Resistance Antineoplastic Agents Review Pathogenesis Disease Cytokine storm medicine.disease_cause Immune system Neoplasms Genetics Humans Medicine Molecular Biology Coronavirus Chemotherapy SARS-CoV-2 business.industry COVID-19 Cancer General Medicine medicine.disease Cancer cell Immunology Cytokine Release Syndrome Chemotherapy resistance business |
| Zdroj: | Molecular Biology Reports |
| ISSN: | 1573-4978 0301-4851 |
| DOI: | 10.1007/s11033-021-06800-4 |
| Popis: | Objective: Severe acute respiratory syndrome coronavirus 2 (SARS-COV2) was first detected in Wuhan, China in December, 2019. The emerging virus causes a respiratory illness, that can trigger a cytokine storm in the body. Method: Cytokine storm in patient's body is associated with severe forms of disease. It is one of the main complications of coronavirus disease-2019 (COVID-19), in which immune cells play a major role. Studies have shown immune cells in the tumor environment can be effective to induce resistance to chemotherapy in cancer patients. Result: Therefore, considering the role of immune cells to induce cytokine storm in COVID-19 patients, and their role to cause resistance to chemotherapy, they are effective on disease progression and creation of severe form of disease. Conclusion: By examining the signaling pathways and inducing resistance to chemotherapy in tumor cells and the cells affect them, it is possible to prevent the occurrence of severe forms of the disease in cancer patients with COVID-19; it is applicable using target therapy and other subsequent treatment strategies. |
| Databáze: | OpenAIRE |
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