Striatal amphetamine-induced dopamine release in patients with schizotypal personality disorder studied with single photon emission computed tomography and [123I]iodobenzamide
| Autor: | Vivian Mitropoulou, Larry J. Siever, Harold W. Koenigsberg, Anissa Abi-Dargham, Diana Martinez, Lawrence S. Kegeles, Osama Mawlawi, Karen O'Flynn, Thomas B. Cooper, Yolanda Zea-Ponce, Ronald L. Van Heertum, Marc Laruelle |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Pyrrolidines Dopamine Schizoid Personality Disorder Single-photon emission computed tomography Iodine Radioisotopes chemistry.chemical_compound Iodobenzamide Internal medicine Dopamine receptor D2 mental disorders Basal ganglia medicine Humans Amphetamine Neurotransmitter Biological Psychiatry Psychiatric Status Rating Scales Tomography Emission-Computed Single-Photon Analysis of Variance medicine.diagnostic_test Receptors Dopamine D2 Middle Aged medicine.disease Schizotypal personality disorder Corpus Striatum Endocrinology chemistry Case-Control Studies Benzamides Dopamine Antagonists Central Nervous System Stimulants Female Psychology Neuroscience medicine.drug |
| Zdroj: | Biological Psychiatry. 55:1001-1006 |
| ISSN: | 0006-3223 |
| DOI: | 10.1016/j.biopsych.2004.01.018 |
| Popis: | Background Previous imaging studies demonstrated that schizophrenia is associated with increased amphetamine-induced dopamine (DA) release in the striatum, most pronounced during episodes of illness exacerbation. Schizotypal personality disorder (SPD) is a schizophrenia spectrum disorder, genetically related to schizophrenia. The goal of this study was to investigate striatal DA function in patients with SPD. Methods In our study, 13 SPD patients and 13 matched healthy control subjects underwent single photon emission computed tomography (SPECT) scan during bolus plus constant infusion of the D2/3 radiotracer [123I]iodobenzamide (IBZM). Striatal specific to nonspecific equilibrium partition coefficient (V3′′) was measured at baseline and following amphetamine administration (.3 mg/kg). Results No significant differences were observed in baseline V3′′ between groups. Amphetamine induced a larger decrease in [123I]IBZM V3′′ in SPD patients (−12 ± 5%) compared with control subjects (−7 ± 5%, p = .03). Conclusions The reduction in [123I]IBZM V3′′ induced by amphetamine in SPD was similar to that observed in remitted schizophrenia patients (−10 ± 9%, n = 17), but significantly lower than that observed during illness exacerbation (−24 ± 13%, n = 17). This suggests that DA dysregulation in schizophrenia spectrum disorders might have a trait component, present in remitted patients with schizophrenia and in SPD, and a state component, associated with psychotic exacerbations but not SPD. |
| Databáze: | OpenAIRE |
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