Antibiotic Synergy Interaction against Multidrug-Resistant Pseudomonas aeruginosa Isolated from an Abattoir Effluent Environment
| Autor: | Emmanuel E. Odjadjare, Isoken H. Igbinosa, Etinosa O. Igbinosa, Phillips O. Orhue, May N. O. Omoigberale, Napoleon I. Amhanre |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Imipenem
Article Subject Cell Survival Cefepime lcsh:Medicine Industrial Waste Biology medicine.disease_cause lcsh:Technology Meropenem General Biochemistry Genetics and Molecular Biology Agar dilution Microbiology Drug Resistance Multiple Bacterial medicine lcsh:Science Etest General Environmental Science lcsh:T Pseudomonas aeruginosa lcsh:R Pseudomonas Drug Synergism General Medicine biology.organism_classification Anti-Bacterial Agents Amikacin lcsh:Q Water Microbiology Abattoirs medicine.drug Research Article |
| Zdroj: | The Scientific World Journal The Scientific World Journal, Vol 2012 (2012) |
| ISSN: | 1537-744X 2356-6140 |
| Popis: | Pseudomonas aeruginosais an opportunistic pathogen in environmental waters with a high prevalence of multidrug resistance. In this study the synergistic efficacy of synergy antibiotic combinations in multidrug-resistantP. aeruginosastrains isolated from an abattoir effluent was investigated. Water samples were processed using membrane filtration;Pseudomonaswas isolated with Pseudomonas Isolation Agar and confirmed using polymerase chain reaction with specie-specific primer. Susceptibility studies andin vitrosynergy interaction testing were carried out, employing agar dilution and Etest procedure, respectively. Resistance was noted for clinically relevant antipseudomonal agents tested. Finding from antibiotic synergy interaction studies revealed that cefepime, imipenem, and meropenem combined with amikacin resulted in statistically significant (P<0.0001)in vitroantibiotics synergy interaction, indicating the possible use of this regimen in treatment of pseudomonal infections. |
| Databáze: | OpenAIRE |
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