Gene expression differences in primary colorectal tumors and matched liver metastases: chemotherapy related or tumoral heterogeneity?
| Autor: | Enrique Casado, Ines Suarez-Garcia, Paloma Cejas, D. Fernández-Luengas, César Gómez-Raposo, Jaime Feliu, Rosario Madero, Ana Maria Jimenez, Francisco Zambrana, Miriam López-Gómez, Juan Moreno-Rubio, María Merino, María Sereno |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A Oncology Cancer Research medicine.medical_specialty Colorectal cancer medicine.medical_treatment Antineoplastic Agents Real-Time Polymerase Chain Reaction CXCR4 Internal medicine Gene expression medicine Humans Gene Aged Retrospective Studies Smad4 Protein Aged 80 and over Chemotherapy business.industry Gene Expression Profiling Liver Neoplasms General Medicine Middle Aged Endonucleases medicine.disease Primary tumor Neoplasm Proteins DNA-Binding Proteins Female DPYD ERCC1 Colorectal Neoplasms business |
| Zdroj: | Clinical and Translational Oncology. 17:322-329 |
| ISSN: | 1699-3055 1699-048X |
| DOI: | 10.1007/s12094-014-1233-3 |
| Popis: | Treatment of metastatic colorectal cancer (mCRC) is generally based on genetic testing performed in primary tumor biopsies, but whether the genomic status of primary tumors is identical to that of metastases is not well known. We compared the gene expression profiles of formalin-fixed paraffin-embedded (FFPE) biopsies of colorectal primary tumors and matched liver metastases. We compared the expression of 18 genes in FFPE CRC tumors and their matched liver metastases from 32 patients. The expression of each gene in CRC primary tumors and their matched liver metastases was tested using Student’s t test for paired samples. Pairwise correlations of each gene in the primary tumors and matched liver metastases were evaluated by Pearson’s correlation coefficient. The expression of six genes was significantly different in primary tumors compared with their matched liver metastases [CXCR4 (p |
| Databáze: | OpenAIRE |
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