A genome-wide association study on confection consumption in a Japanese population: the Japan Multi-Institutional Collaborative Cohort Study
| Autor: | Kenji Wakai, Yasuyuki Nakamura, Yoshikuni Kita, Taro Suzuki, Aya Kadota, Yohko Nakamura, Akira Narita, Hiroaki Ikezaki, Michiaki Kubo, Nagato Kuriyama, Kokichi Arisawa, Kenji Matsui, Katsuyuki Miura, Masahiro Nakatochi, Isao Oze, Megumi Hara, Yukio Doi, Yukihide Momozawa, Sadao Suzuki, Atsushi Shimizu, Keitaro Matsuo, Toshiro Takezaki, Nahomi Imaeda, Etsuko Ozaki, Kiyonori Kuriki, Daisaku Nishimoto, Sakurako Katsuura-Kamano, Keitaro Tanaka, Kenji Takeuchi, Chiho Goto, Haruo Mikami, Miki Watanabe, Masayuki Murata |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Alcohol Drinking Medicine (miscellaneous) Single-nucleotide polymorphism Genome-wide association study Biology Affect (psychology) Polymorphism Single Nucleotide Acyl-CoA Dehydrogenase alcohol intake confounding Candy Cohort Studies Eating 03 medical and health sciences 0302 clinical medicine Japan TAS1R2 Statistical significance Genetic variation Humans Consumption (economics) Nutrition and Dietetics digestive oral and skin physiology 030104 developmental biology aldehyde dehydrogenase 2 (ALDH2) sweet food consumption 030217 neurology & neurosurgery Genome-Wide Association Study Demography Cohort study |
| Zdroj: | British Journal of Nutrition. 126:1843-1851 |
| ISSN: | 1475-2662 0007-1145 |
| DOI: | 10.1017/s0007114521000684 |
| Popis: | Differences in individual eating habits may be influenced by genetic factors, in addition to cultural, social or environmental factors. Previous studies suggested that genetic variants within sweet taste receptor genes family were associated with sweet taste perception and the intake of sweet foods. The aim of this study was to conduct a genome-wide association study (GWAS) to find genetic variations that affect confection consumption in a Japanese population. We analysed GWAS data on confection consumption using 14 073 participants from the Japan Multi-Institutional Collaborative Cohort study. We used a semi-quantitative FFQ to estimate food intake that was validated previously. Association of the imputed variants with confection consumption was performed by linear regression analysis with adjustments for age, sex, total energy intake and principal component analysis components 1–3. Furthermore, the analysis was repeated adjusting for alcohol intake (g/d) in addition to the above-described variables. We found 418 SNP located in 12q24 that were associated with confection consumption. SNP with the ten lowest P-values were located on nine genes including at the BRAP, ACAD10 and aldehyde dehydrogenase 2 regions on 12q24.12-13. After adjustment for alcohol intake, no variant was associated with confections intake with genome-wide significance. In conclusion, we found a significant number of SNP located on 12q24 genes that were associated with confections intake before adjustment for alcohol intake. However, all of them lost statistical significance after adjustment for alcohol intake. |
| Databáze: | OpenAIRE |
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