In vitro Activity of Ampicillin Alone and in Combination with Different Concentrations of 6 Beta-bromopenicillanic Acid, Clavulanic Acid and Mecillinam
| Autor: | Stobberingh Ee, van Boven Cp, Houben Aw |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Microbiology (medical)
Cefotaxime Penicillanic Acid Ceftazidime Microbial Sensitivity Tests Microbiology Clavulanic Acids Enterobacteriaceae Ampicillin Clavulanic acid polycyclic compounds medicine Drug Interactions Mecillinam Clavulanic Acid General Immunology and Microbiology biology Chemistry Amdinocillin Drug Synergism General Medicine biochemical phenomena metabolism and nutrition biology.organism_classification In vitro Drug Combinations Infectious Diseases beta-Lactamase Inhibitors Antibacterial activity medicine.drug |
| Zdroj: | Scandinavian Journal of Infectious Diseases. 19:105-112 |
| ISSN: | 1651-1980 0036-5548 |
| DOI: | 10.3109/00365548709032385 |
| Popis: | The antibacterial activity of ampicillin against Enterobacteriaceae strongly increased when combined with 6 beta-bromopenicillanic acid (BPA) or clavulanic acid (CA). In vitro, the combination ampicillin: BPA in the ratio 1:1 proved to be the most effective one. The antibacterial activity of mecillinam against Enterobacteriaceae was strongly potentiated by the addition of ampicillin. The combination mecillinam: ampicillim in the ratio 4:5 showed an antibacterial activity comparable to that of new beta-lactam compounds such as cefotaxime and ceftazidime. |
| Databáze: | OpenAIRE |
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