Imaging Manifestations of Hematologic Diseases with Renal and Perinephric Involvement
| Autor: | Christopher P. Coppa, Antonio C. Westphalen, Andrei S. Purysko, Brian R. Herts, Erick M. Remer, Hilton Leão Filho |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.diagnostic_test business.industry Hemosiderosis medicine.disease Hematologic Diseases Renal Circulation 030218 nuclear medicine & medical imaging Adipose capsule of kidney Diagnosis Differential Renal medullary carcinoma 03 medical and health sciences Histiocytosis 0302 clinical medicine 030220 oncology & carcinogenesis Biopsy medicine Humans Kidney Diseases Radiology Nuclear Medicine and imaging Differential diagnosis business Nephrotic syndrome Multiple myeloma |
| Zdroj: | RadioGraphics. 36:1038-1054 |
| ISSN: | 1527-1323 0271-5333 |
| DOI: | 10.1148/rg.2016150213 |
| Popis: | The kidneys and perinephric tissues can be affected by a variety of hematologic disorders, which usually occur in the setting of multisystem involvement. In many of these disorders, imaging is used to evaluate the extent of disease, guide biopsy, and/or monitor disease activity and patient response to therapy. Lymphoma, leukemia, and multiple myeloma commonly manifest as multiple parenchymal or perinephric lesions. Erdheim-Chester disease and Rosai-Dorfman disease, rare forms of multisystemic histiocytosis, are often identified as perinephric and periureteral masses. Renal abnormalities depicted at imaging in patients with sickle cell disease include renal enlargement, papillary necrosis, and renal medullary carcinoma. Sickle cell disease, along with other causes of intravascular hemolysis, can also lead to hemosiderosis of the renal cortex. Thrombosis of renal veins is sometimes seen in patients with coagulation disorders but more often occurs in association with certain malignancies and nephrotic syndrome. Immunoglobulin G4-related sclerosing disease is another multisystem process that often produces focal renal lesions, seen along with involvement of more characteristic organs such as the pancreas. Perinephric lesions with calcifications should raise the possibility of secondary amyloidosis, especially in patients with a history of lymphoma and multiple myeloma. Although the imaging patterns of renal and perinephric involvement are usually not specific for a single entity, and the same entity can manifest with different or overlapping patterns, familiarity with these patterns and key clinical and histopathologic features may help to narrow the differential diagnosis and determine the next step of care. (©)RSNA, 2016. |
| Databáze: | OpenAIRE |
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