Oxidative stress and ferritin levels in haemodialysis patients
| Autor: | Alpaslan Ersoy, Selda Erdinc, Emre Sarandol, Mustafa Yurtkuran, Emel Senol |
|---|---|
| Přispěvatelé: | Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı., Şenol, Emel, Ersoy, Alpaslan, Sarandol, Emre, Yurtkuran, Mustafa, Erdinç, Selda, ABE-1716-2020 |
| Rok vydání: | 2007 |
| Předmět: |
Male
Apolipoprotein B High density lipoprotein Low density lipoprotein Hemodialysis Ascorbic Acid Deficiency Chronic Kidney Failure Lipid peroxidation Plasma chemistry.chemical_compound Chronic kidney-disease Medicine Urology & nephrology Arylesterase Enzyme activity Calcidiol 1 monooxygenase Priority journal Stage renal-disease C reactive protein medicine.diagnostic_test biology Malonaldehyde Serum paraoxonase Lipid-peroxidation Haemodialysis Cholesterol blood level Nephrology Hypertension Angiotensin receptor antagonist Ascorbic acid Female Human Adult medicine.medical_specialty Iron Clinical article Superoxide dismutase Triacylglycerol Article Calcitriol Renal Dialysis Internal medicine Humans Ferritin blood level Recombinant erythropoietin Erythropoietin Nutrition Uremia Inflammation Ferritin Transplantation Aryldialkylphosphatase business.industry Protein Albumin Calcium channel blocking agent Iron deficiency C-reactive protein Paraoxonase Beta adrenergic receptor blocking agent Atherosclerosis Oxidative Stress Endocrinology chemistry Ferritins Glutathione peroxidase biology.protein Dipeptidyl carboxypeptidase inhibitor Lymphocyte count Oxidant stress business Lipid profile Iron therapy Controlled study |
| Zdroj: | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 23(2) |
| ISSN: | 1460-2385 |
| Popis: | Background. Increased oxidative stress (OS) and inflammation are associated with atherosclerotic coronary artery disease in haemodialysis (HD) patients. Ferritin may have other effects in addition to its role in storing intracellular iron. This study was performed to determine any relationships between markers of OS, nutrition and inflammation in HD patients with normal and high ferritin levels. Methods. Our cohort comprised 34 maintenance dialysis patients on erythropoietin therapy and 22 healthy controls. HD patients were divided into two groups: 17 with normal (800 ng/ml) ferritin levels, and we measured lipid profile, albumin, highly sensitive C-reactive protein (hsCRP), anti-oxidant enzymes [whole blood glutathione peroxidase (Gpx), serum superoxide dismutase (SOD), paraoxonase, arylestherase (AE) and total anti-oxidant status (TAOC)], anti-oxidants (vitamin C) and lipid peroxidation products [red blood cell malondialdehyde (RBC MDA)]. Results. Compared with controls, the HD patients had higher serum urea, blood pressure, triglyceride, hsCRP, RBC MDA, SOD and TAOC values and lower albumin, low-density lipoprotein cholesterol, apolipoprotein AI, paraoxonase, AE and whole blood Gpx activities. Serum vitamin C, uric acid, apolipoprotein B, total- and high-density lipoprotein cholesterol, apolipoprotein B MDA, and lymphocyte levels in the HD patients with normal and high ferritin levels were similar. The OS markers of HD patients did not differ, whether or not they received intravenous iron supplementation or had transferrin saturations = 50. Conclusion. HD patients are in a higher oxidative state, which results in the reduction of total anti-oxidant capacity and also have an increased inflammation status. We could not find a relationship between ferritin level and OS markers in HD patients receiving erythropoietin. |
| Databáze: | OpenAIRE |
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