Nutraceuticals: A New Challenge against Cadmium-Induced Testicular Injury
| Autor: | Herbert Ryan Marini, Antonio Micali, Giovanni Squadrito, Domenico Puzzolo, José Freni, Pietro Antonuccio, Letteria Minutoli |
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| Rok vydání: | 2021 |
| Předmět: |
nutraceuticals
Male Nutrition and Dietetics Nutrition. Foods and food supply apoptosis Cadmium testis oxidative stress inflammation apoptosis blood–testis barrier infertility nutraceuticals Mediterranean diet Diet Oxidative Stress inflammation Mediterranean diet Dietary Supplements Testis Humans TX341-641 blood–testis barrier infertility Food Science Cadmium |
| Zdroj: | Nutrients, Vol 14, Iss 663, p 663 (2022) |
| ISSN: | 2072-6643 |
| Popis: | Cadmium (Cd) is a widespread heavy metal and a ubiquitous environmental toxicant. For the general population, the principal causes of Cd exposure are cigarette smoking, air pollution and contaminated water and food consumption, whereas occupational exposure usually involves humans working in mines or manufacturing batteries and pigments that utilize Cd. The aim of the present review is to evaluate recent data regarding the mechanisms of Cd-induced testicular structural and functional damages and the state of the art of the therapeutic approaches. Additionally, as the current literature demonstrates convincing associations between diet, food components and men’s sexual health, a coherent nutraceutical supplementation may be a new valid therapeutic strategy for both the prevention and alleviation of Cd-induced testicular injury. The toxic effects on testes induced by Cd include many specific mechanisms, such as oxidative stress, inflammation and apoptosis. As no specific therapy for the prevention or treatment of the morbidity and mortality associated with Cd exposure is available, the development of new therapeutic agents is requested. Dietary strategies and the use of nutraceuticals, particularly abundant in fresh fruits, beans, vegetables and grains, typical of the Mediterranean diet, are recommended against Cd-induced testicular injury. |
| Databáze: | OpenAIRE |
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