Neural Glyoxalase Pathway Enhancement by Morin Derivatives in an Alzheimer’s Disease Model
| Autor: | Prabagaran Narayanasamy, Seoung Ryoung Choi, Joel Frandsen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Antioxidant
Physiology Cognitive Neuroscience medicine.medical_treatment Flavonoid Inflammation Morin medicine.disease_cause Biochemistry Antioxidants 03 medical and health sciences chemistry.chemical_compound Lactoylglutathione lyase 0302 clinical medicine Alzheimer Disease Neural Pathways medicine Animals 030304 developmental biology Flavonoids Neurons chemistry.chemical_classification 0303 health sciences biology Methylglyoxal Lactoylglutathione Lyase Cell Biology General Medicine Glutathione Pyruvaldehyde Mice Inbred C57BL Oxidative Stress chemistry biology.protein medicine.symptom 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | ACS Chemical Neuroscience. 11:356-366 |
| ISSN: | 1948-7193 |
| DOI: | 10.1021/acschemneuro.9b00566 |
| Popis: | The glyoxalase pathway (GP) is an antioxidant defense system that detoxifies metabolic byproduct methylglyoxal (MG). Through sequential reactions, reduced glutathione (GSH), glyoxalase I (glo-1), and glyoxalase II (glo-2) convert MG into d-lactate. Spontaneous reactions involving MG alter the structure and function of cellular macromolecules through the formation of inflammatory advanced glycation endproducts (AGEs). Accumulation of MG and AGEs in neural cells contributes to oxidative stress (OS), a state of elevated inflammation commonly found in neurodegenerative diseases including Alzheimer's disease (AD). Morin is a common plant-produced flavonoid polyphenol that exhibits the ability to enhance the GP-mediated detoxification of MG. We hypothesize that structural modifications to morin will improve its inherent GP enhancing ability. Here we synthesized a morin derivative, dibromo-morin (DBM), formulated a morin encapsulated nanoparticle (MNP), and examined their efficacy in enhancing neural GP activity. Cultured mouse primary cerebellar neurons and |
| Databáze: | OpenAIRE |
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