A novel variant three-way translocation of inversion 16 in a case of AML-M4eo following low dose methotrexate therapy
| Autor: | George H. Thomas, Michael J. Borowitz, Alan D. Friedman, Rima J. Couzi, Shiyong Li |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Chromosomal translocation Biology Leukemia Myelomonocytic Acute Translocation Genetic Complex Karyotype Antineoplastic Combined Chemotherapy Protocols Genetics MYH11 medicine Humans Molecular Biology Chromosomal inversion Aged DNA Primers Base Sequence Reverse Transcriptase Polymerase Chain Reaction Pemphigus vulgaris Cytogenetics medicine.disease Methotrexate Fusion transcript Immunology Acute myelomonocytic leukemia Chromosome Inversion Cancer research Chromosomes Human Pair 16 Pemphigus |
| Zdroj: | Cancer genetics and cytogenetics. 125(1) |
| ISSN: | 0165-4608 |
| Popis: | We report a case of acute myelomonocytic leukemia with eosinophilia (AML-M4eo) in a 65-year-old man following low dose methotrexate treatment for pemphigus vulgaris. Cytogenetic studies at diagnosis revealed a complex karyotype including a reciprocal translocation between 11q14.2 and 16q22, an inversion of chromosome 16(p13.1q22), and an apparently terminal deletion of 7q31. The presence of inv(16) was confirmed by reverse transcription-polymerase chain reaction which demonstrated a Type A fusion transcript derived from the core binding factor (CBF) beta and the smooth muscle myosin heavy chain (MYH11) genes. The patient was in complete hematologic and cytogenetic remission 6 months following intensive chemotherapy. Because AML-M4eo with inv(16) has a favorable prognosis, molecular studies should be performed in case the identification of inv(16) by conventional cytogenetics is difficult due to a complex karyotype. |
| Databáze: | OpenAIRE |
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