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Lumbar 1 vertebrae are among those most commonly fracture due to osteoporosis. The strength of human vertebrae and its structural, microstructural and material determinants have been the subject of numerous studies. However, a comprehensive evaluation of properties beyond maximum load to fracture has not been available for the L1 vertebrae. The objective of this study was to document these properties in association with each other and with the geometric, density and cancellous and cortical structure properties for human L1 vertebrae. Bone volume fraction (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), trabecular separation (Tb.Sp), connectivity density (Conn.Dn), degree of anisotropy (DA), structure model index (SMI) and fractal dimension (FD) of the cancellous microstructure, tissue mineral density (TMD), and thickness of the cortical shell (Sh.Th) and superior and inferior endplates thicknesses (EP.Th.S and EP.Th.I) were measured using microcomputed tomography for 27 cadaveric L1 vertebrae. Volumetric cancellous, shell and integral bone mineral densities (vBMD, shBMD and iBMD) as well as vertebral volume (V), height and width were measured using high resolution CT. Areal whole vertebral body and regional BMDs were measured using dual energy x-ray absorptiometry (DXA) in coronal and lateral views. Specimens were then uniaxially compressed to 15% of their height to obtain vertebral stiffness (K) and strength (F |
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