Protective efficacy of an RBD-based Middle East respiratory syndrome coronavirus (MERS-CoV) particle vaccine in llamas

Autor: Rodon, Jordi, Mykytyn, Anna Z, Cantero, Guillermo, Albulescu, Irina C, Bosch, Berend-Jan, Brix, Alexander, Audonnet, Jean-Christophe, Bensaid, Albert, Vergara-Alert, Júlia, Haagmans, Bart L, Segalés, Joaquim, Virologie, dI&I I&I-1
Přispěvatelé: Virologie, dI&I I&I-1, Producció Animal, Sanitat Animal
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: One Health Outlook, 4(1), 1
One Health Outlook
IRTA Pubpro. Open Digital Archive
Institut de Recerca i Tecnologia Agroalimentàries (IRTA)
ISSN: 2524-4655
Popis: Ongoing outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) continue posing a global health threat. Vaccination of livestock reservoir species is a recommended strategy to prevent spread of MERS-CoV among animals and potential spillover to humans. Using a direct-contact llama challenge model that mimics naturally occurring viral transmission, we tested the efficacy of a multimeric receptor binding domain (RBD) particle-display based vaccine candidate. While MERS-CoV was transmitted to naïve animals exposed to virus-inoculated llamas, immunization induced robust virus-neutralizing antibody responses and prevented transmission in 1/3 vaccinated, in-contact animals. Our exploratory study supports further improvement of the RBD-based vaccine to prevent zoonotic spillover of MERS-CoV.
Databáze: OpenAIRE
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