Selective 5-HT7 receptor agonists LP 44 and LP 211 elicit an analgesic effect on formalin-induced orofacial pain in mice
| Autor: | Buğra Şenel, Melik Seyrek, Ahmet Doğrul, Enza Lacivita, Kadriye Demirkaya, Marcello Leopoldo, Zeynep Öncel Torun, Özlem Martı Akgün |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Agonist Orofacial pain Time Factors medicine.drug_class Analgesic Pharmacology Piperazines 5-HT7 receptor Mice 03 medical and health sciences 0302 clinical medicine Receptor agonists Facial Pain Formaldehyde Animals Medicine Trigeminal Nerve Receptor General Dentistry Analgesics Mice Inbred BALB C Dose-Response Relationship Drug business.industry Reproducibility of Results Original Articles Serotonin Receptor Agonists lcsh:RK1-715 Formalin Disease Models Animal Treatment Outcome 030104 developmental biology Nociception lcsh:Dentistry Receptors Serotonin Substantia Gelatinosa Anesthesia Serotonin medicine.symptom business LP-44 030217 neurology & neurosurgery |
| Zdroj: | Journal of Applied Oral Science v.24 n.3 2016 Journal of applied oral science Universidade de São Paulo (USP) instacron:USP Journal of Applied Oral Science, Volume: 24, Issue: 3, Pages: 218-222, Published: JUN 2016 Journal of Applied Oral Science Journal of Applied Oral Science, Vol 24, Iss 3, Pp 218-222 |
| Popis: | The most recently identified serotonin (5-HT) receptor is the 5-HT7 receptor. The antinociceptive effects of a 5-HT7 receptor agonist have been shown in neuropathic and inflammatory animal models of pain. A recent study demonstrated the functional expression of 5-HT7 receptors in the substantia gelatinosa (SG) of the trigeminal subnucleus caudalis, which receives and processes orofacial nociceptive inputs. Objective To investigate the antinociceptive effects of pharmacological activation of 5-HT7 receptors on orofacial pain in mice. Material and Methods Nociception was evaluated by using an orofacial formalin test in male Balb-C mice. Selective 5-HT7 receptor agonists, LP 44 and LP 211 (1, 5, and 10 mg/kg), were given intraperitoneally 30 min prior to a formalin injection. A bolus of 10 µl of 4% subcutaneous formalin was injected into the upper lip of mice and facial grooming behaviors were monitored. The behavioral responses consisted of two distinct periods, the early phase corresponding to acute pain (Phase I: 0–12 min) and the late phase (Phase II: 12–30 min). Results LP 44 and LP 211 (1, 5, and 10 mg/kg) produced an analgesic effect with reductions in face rubbing time in both Phase I and Phase II of the formalin test. Conclusion Our results suggest that 5-HT7 receptor agonists may be promising analgesic drugs in the treatment of orofacial pain. |
| Databáze: | OpenAIRE |
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