Small cell lung cancer: updates and new concepts
Autor: | Peter Ujhazy, O. Wolf Lindwasser |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty medicine.medical_treatment Disease 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Lung cancer neoplasms Etoposide Limited Stage business.industry Recurrent SCLC medicine.disease humanities respiratory tract diseases Radiation therapy 030104 developmental biology Preface on Small Cell Lung Cancer: New Models Markers and Beyond 030220 oncology & carcinogenesis Topotecan Non small cell business medicine.drug |
Zdroj: | Translational Lung Cancer Research. 7:1-3 |
ISSN: | 2226-4477 2218-6751 |
Popis: | The standard of care for both limited stage and extensive stage SCLC has seen little change since the introduction of platinum/etoposide doublet therapy in the mid-1980s (1,2). There have been advances in the clinic since then, including the approval of topotecan for recurrent SCLC and the application of new radiation therapy strategies, but despite these advances the outlook for patients afflicted with SCLC remains dismal (3-8). The frequent and rapid incidence of acquired resistance to these therapies (6) and the inability to detect early-stage disease by radiographic approaches (9-11) has bedeviled progress in this deadly disease. |
Databáze: | OpenAIRE |
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