Discordance between fetal RhD typing using molecular methods and neonatal typing with serology
| Autor: | Jerome Yankowitz, Ignatia B. Van den Veyver, Stephanie B. Subramanian, Kenneth J. Moise, Karen F. Dorman |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Amniotic fluid Genotype Prenatal diagnosis Gestational Age Biology Rh Isoimmunization Polymerase Chain Reaction law.invention Serology Erythroblastosis Fetal law Pregnancy Humans Typing Genotyping False Negative Reactions Polymerase chain reaction Blood type Rh-Hr Blood-Group System Infant Newborn Obstetrics and Gynecology Amniotic Fluid Reproductive Medicine Blood Grouping and Crossmatching Immunology Female Rh blood group system |
| Zdroj: | Gynecologic and obstetric investigation. 48(4) |
| ISSN: | 0378-7346 |
| Popis: | Polymerase chain reaction (PCR)-based genotyping on amniotic fluid in an RhD-negative alloimmunized woman predicted an RhD-negative fetal blood type. The neonate was RhD-positive and developed hemolytic disease. Discrepant results were also observed on paternal testing. PCR analysis with a different set of primers correctly predicted the RhD-positive fetal and paternal blood type. Use of more than one set of primers and parental testing can avoid some of the problems associated with use of PCR genotyping. |
| Databáze: | OpenAIRE |
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