Focused library approach for identification of new N-acylphenylalanines as VCAM/VLA-4 antagonists
| Autor: | Karen Rowan, Jefferson Wright Tilley, Richard V. Trilles, Dorota Miklowski, Virginia Schwinge, Li Chen, Tai-Nan Huang, Robert M. Campbell, David C. Fry |
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| Rok vydání: | 2002 |
| Předmět: |
Models
Molecular Molecular Structure Chemistry Phenylalanine Organic Chemistry Clinical Biochemistry Antagonist Vascular Cell Adhesion Molecule-1 Pharmaceutical Science VLA-4 Computational biology Integrin alpha4beta1 Biochemistry Cell Line Drug Discovery Benzene derivatives Molecular Medicine Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 12:1679-1682 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(02)00201-9 |
| Popis: | A structure-based focused library approach was employed in an effort to identify more lipophilic replacements for the N-benzylpyroglutamyl group of the VCAM/VLA-4 antagonist 2. This effort led to the discovery of two new classes of potent antagonists characterized by the N-(alpha-phenylcyclopentanoyl- and the N-(2,6-dimethylbenzoyl)-derivatives 60 and 64. |
| Databáze: | OpenAIRE |
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